The Ultimate Site of Worms Armageddon
Other Things => Off Topic => Topic started by: SPW on April 05, 2013, 09:14 PM
-
:)
-
2.5kilometres? lol holy shit???
My 1st name was PudgieBudgie lol, I swapped to TheKomodo in 2000 very shortly after the release of Mauro Picotto - Komodo (Save a soul) my favourite song of all time, will always remind me of my Grandfather.
-
I smoked about 2.5km weed in my life but no clue about played worms games. Must be over 10k, first touch with worms was back to 95 played on my Amiga before first steps into net-gaming at 98. My nick was "SwissPowerWorms" so from the beginning I was always "SPW" :D
im a bit worried about how f@#!ed up your lungs are lol
-
Getting some health points back cause I dont drink and I'm not fat. ;D
-
I dont drink
How the hell do you survive? :P
-
easy
-
Lmfao sock, i'd actually give this guy money lol, for being honest :)
Jus like this sign I seen in London years ago "Homeless and need money for vodka" and underneath it said "Hey, at least i'm honest!" haha :D
Needless to say his hat was full :)
-
smoking weed doesn't hurt your lungs
-
smoking weed doesn't hurt your lungs
Uh yes it does. Especially if you smoke from joints, the burning process itself creates harmful toxins
-
google search: marijuana lungs - gives me nothing but studies that say the opposite
-
wtf is 2.5 km? u mean 2,5 kg or wtf how u count weed in distance??
-
smoking weed doesn't hurt your lungs
Uh yes it does. Especially if you smoke from joints, the burning process itself creates harmful toxins
the burning process of the paper, not the green
-
Read some articles. interesting and new information for me. Made me feel happy actually, I've thought I've made a lot of damage in my years of smoking a lot of weed. Sure some damage has been done because I've mixed with tobacco, but not as bad as I've thought.
Hoorah!
THC might be actually beneficial for lung function hah. Kills aging cells so they dont become so "cancer-prone", studies seem to show.
-
Yes that's true Free, but weed in long term definetely damage your brain, don't you think?
-
Yes that's true Free, but weed in long term definetely damage your brain, don't you think?
Lack of brain exercise and lack of reading could potentially be worse in the long term for the brain of a person than THC. Either way, it should be judged in a case to case scenario and surely keep politics out of it.
-
Each person reacts differently to THC, if used correctly and the person is lucky enough to have a body that benefits from it then happy days :)
It can still f@#! people up if their body can't handle it, ropa is right for once though, keep politics out of it.
IMO - Weed > Alcohol
-
ive been smoking weed(never ciggs) everyday for over 10 years and i still run the mountains everyday like a damn mountain goat, and as for brain cells im still able to cut a gemstone with over 200 facets after smoking a joint... well several joints i guess u cant cut the top and bottom without switching up the glue which takes a couple hours to dry
as for drinking i feel that taking a toll on me alot more then smoking, and ive been doing it for less time
-
smoking weed doesn't hurt your lungs
Facepalm. It's not like smoking cigarettes shy, but come on. I could cite some sources, but i only really need common sense to determine that inhaling smoke into my lungs isn't good for my body. If you are using a vaporizer then it is a totally different scenario, I don't think there is any danger in that.
-
smoking weed doesn't hurt your lungs
Facepalm. It's not like smoking cigarettes shy, but come on. I could cite some sources, but i only really need common sense to determine that inhaling smoke into my lungs isn't good for my body. If you are using a vaporizer then it is a totally different scenario, I don't think there is any danger in that.
Really warm milk kills cells on its way down your throat. It's a matter of taking everything into account.
For all I know, under the right system, gun possession could work. People are allowed to drive cars after all right?. I know it's lazy to just point at politics as the origin of all evil, but it's easier to get a vote going against a popular enemy than working out a system for it to properly work.
I think Holland is still last in deaths per cannabis overdose amongst European countries.
-
:)
-
Ropa is one of a few persons that can actually question Komo in this kind of situation, even if it's a ridiculous one. The generation of the 90's is dying out, slowly, I'm happy some are still around to be honest. Hope we meet in a few months Ropa
-
IMO - Weed > Alcohol
100% !!!
And btw, with "I dont drink" I meant I dont drink alcohol. In german language you say it like that. ;D
I don't understand why you would prefer weed infront of alcohol SPW. I have tried weed, and never again! Atleast you socialise when drinking alcohol with friends. I can't imagine socializing smoking weed. I didn't know you smoked a lot of it SPW ;X
-
alcohol - makes you lose motor functions, has countless health risks, is addictive, usually causes unwarranted aggression
weed - in control, no health risks, non addictive, mellows you out
Can't believe there's not a single place in the world where marijuana is completely legalized. people will wake up soon
-
Yea, they will awake, but too late.
-
my new best friend
-
I quote franz
-
I think Holland is still last in deaths per cannabis overdose amongst European countries.
Deaths caused by cannabis overdose? Did you by any chance inject yourself with 20 marihuanas to come up with this statement?
-
haha, I think he was joking... as far as I know, there has never been a death by marijuana overdose in the history of mankind
-
(http://i1058.photobucket.com/albums/t403/jwmassaro/al_gore_excelsior.jpg)
I have to say though, Komodo may just be manbearpig. ???
-
alcohol - makes you lose motor functions, has countless health risks, is addictive, usually causes unwarranted aggression
weed - in control, no health risks, non addictive, mellows you out
Can't believe there's not a single place in the world where marijuana is completely legalized. people will wake up soon
Isn't it legalized in Holland? Anything goes in Holland ;P
-
Isn't it legalized in Holland? Anything goes in Holland ;P
The term isn't legal though, it's some sort of superior dutch understanding of the law, they understand the big picture: if they tried to stop it by force, like everywhere else, they would have drug trafficking and delinquency, like everywhere else, so what they do is adopt a system to control it. I'm sure one of the dutch here can elaborate but the many times I've been in Amsterdam locals always told me the same story about it still being illegal and then went on to explain all these things.
I mean, I believe it's technically illegal to carry weed around, regardless of if it's in your backpack and not in a joint, but they're never going to check. Because tourists camp from coffee shop to coffee shop and obviously they're not going to smoke everything they buy in the first place. I was eating in a terrace one night last summer and I saw like 30 cops walking across a very populated avenue, they formed a wall and starting looking at everyone's backpacks, I was like "great, there goes our 100€ in weed we have on us", turns out, they were just looking for weapons :)
Now, last time I was there, this January, it was already in process of being removed totally (coffee shops included) from all Holland except for Amsterdam, I asked and apparently it's because cities get the last call on enforcing such law and Amsterdam generates a lot of income from weed tourism (nothing compared to the sex tourism, but still).
And they ask for IDs in 99% of the places, and are pretty strict about it (I couldn't get in one because I left my ID at the hotel and I could look 30)
-
Has anyone actually ever heard of ropa doing anything kind hearted for anyone? wtf man, f@#! off ropa...
Yeah, he did, and it's usually pretty funny to be a friend of ropa. :)
He just has a strong personality, if you have one yourself you get along with him even in bad times. :D
-
I have to take a drug test soon for this summer job I'm applying for... such bullshit that you can be a complete alcoholic and be hired yet someone who chooses to use the safer alternative won't get hired if they fail the test... so yeah, I'm currently in detox week, running a mile a day, drinking tons of cranberry juice, and hitting the sauna a lot, although I don't think the cranberry juice or sauna has been scientifically proven to detox your system. It's a urine test, btw
-
Has anyone actually ever heard of ropa doing anything kind hearted for anyone? wtf man, f@#! off ropa...
Yeah, he did, and it's usually pretty funny to be a friend of ropa. :)
He just has a strong personality, if you have one yourself you get along with him even in bad times. :D
i hate your stupid f@#!ing barbarian
-
I have to take a drug test soon for this summer job I'm applying for... such bullshit that you can be a complete alcoholic and be hired yet someone who chooses to use the safer alternative won't get hired if they fail the test... so yeah, I'm currently in detox week, running a mile a day, drinking tons of cranberry juice, and hitting the sauna a lot, although I don't think the cranberry juice or sauna has been scientifically proven to detox your system. It's a urine test, btw
i knew that a week isn't enough. it takes at least 2-3 weeks (or even a month) to get negative results, if its a urine test... it depends tho, some people detox sooner.
-
yeah but I've read success stories from as little as 24 hours. I'm in shape and have pretty low body fat and have high metabolism, so I figure I'll be fine if I take the test in a week and a half
-
if I was an employer I would hire the complete alcoholic instead of a cannabis injector! studies say that even one cannabis needle can kill
-
A friend once told me he had success in a matter of like 4 days, but he was jogging a shitload, like hours every day. It really is bullshit, just an archaic policy that benefits no one.
-
24 hour cleanse is a lie for pot tests, the only time that works is a false negative test.
-
I just wish I knew exactly when I would get the drug test. I've read accounts of other people applying for the same job. Sometimes there are 3 interviews, sometimes there is one... My first one is this Friday, I'm going to try my best to impress the person so I can get hired sooner and get the drug test over with because I f@#!ing love weed and even tho it is non addictive, it's going to suck if I have to wait a whole month to light up
-
if I was an employer I would hire the complete alcoholic instead of a cannabis injector! studies say that even one cannabis needle can kill
so can alcohol needles
-
but people drink alcohol from a bottle
-
http://www.head-shop.de/article/06999/Screeny-Weeny-4.0-Der-Urintesthelfer (http://www.head-shop.de/article/06999/Screeny-Weeny-4.0-Der-Urintesthelfer)
-
but people drink alcohol from a bottle
and some people inject bottles
-
http://www.head-shop.de/article/06999/Screeny-Weeny-4.0-Der-Urintesthelfer (http://www.head-shop.de/article/06999/Screeny-Weeny-4.0-Der-Urintesthelfer)
:o :D
-
24 hour cleanse is a lie for pot tests, the only time that works is a false negative test.
not true, my father drives for a living and gets randomed all of the time and he still smokes everyday... 17 years now i think
@shy keep drinking like you have been, but on your way to go take the test stop at a gas station or something and piss right before u get there, make sure ur drinking so much that you will b able to go again, whats in your system after that basically doesnt have the time to collect anything... sometimes they can make you retest for being too diluted tho
-
if I was an employer I would hire the complete alcoholic instead of a cannabis injector! studies say that even one cannabis needle can kill
No question that alcohol kills worldwide the most. Its the most stupid thing that this drug is legal compare to others (cannabis).
No one cares about an alcoholic next day. But the smoker must have zero. Believe me, you dont have any problems to do your job seriously after a night in between your last smoke.
Where is the tolerance? Where is the fairness?
I saw friends dying and was close to see how alcohol destroyed happy families. My father died cause of alcohol and one of my younger brothers still living in the shit with this legal drug. And thats just my little circle of society. Just math up what it means worldwide.
Dont compare alcohol with cannabis. Cannabis is just mickey-mouse compare to alc.
By the way, I'm talking about alcoholics, not people which drink sometimes a wine to dinner or a beer / week. I talk about addicted people and there are millions of it.
Legalize it!
-
So the conclusion is to legalize another drug because there is one that is more harmful?
-
It seems alcohol really f@#! much more than cannabis if you use everyday.
I have seen many families get f@#!ed up cos of alcohol, mostly of slaves who have almost nothing in life but spend money on alcohol and when get back home, hurts wife and kids, and some others shits.
since i started my bodybuilding life, i rarely drink and i feel rly much better now.
last time i drank i also smoked cannabis and went very crazy huahuahuha xD
-
Oh yeah, definitely don't mix both ! lol
-
So the conclusion is to legalize another drug because there is one that is more harmful?
There are drugs which making you addicted (body and brain). Alcohol and nicotine for example. But not cannabis, its just a mental thing. I coulda stop easily while going half a year to australia or for some other important reasons.
Oh yeah, definitely don't mix both ! lol
When you mix it, the devil comes out! :D No seriously, thats really dangerous if you overkill it.
-
When you mix it, the devil comes out! :D No seriously, thats really dangerous if you overkill it.
yep you can find yourself on philies toilet right after you watched an epic move by lacoste while you are 100% certain to die this night on this f@#!ing toilet ;D
-
There are drugs which making you addicted (body and brain). Alcohol and nicotine for example. But not cannabis, its just a mental thing. I coulda stop easily while going half a year to australia or for some other important reasons.
true, have done this.
-
what was topic again? who has done what drugs the most, wasnt it?
-
First time a Komo-thread turns into something else! :P
-
So the conclusion is to legalize another drug because there is one that is more harmful?
There are drugs which making you addicted (body and brain). Alcohol and nicotine for example. But not cannabis, its just a mental thing. I coulda stop easily while going half a year to australia or for some other important reasons.
I don't really think a drug needs to be addictive to be bad for your health. ^^
-
So the conclusion is to legalize another drug because there is one that is more harmful?
precedents should be looked at when crafting laws like legalizing marijuana. If alcohol is the bar for what can be legal, then f@#! yeah marijuana should be legal
-
weed has killed many more ppl than alcohol
-
So the conclusion is to legalize another drug because there is one that is more harmful?
precedents should be looked at when crafting laws like legalizing marijuana. If alcohol is the bar for what can be legal, then f@#! yeah marijuana should be legal
The problem is that alcohol (and cigarettes) have been an industry for centuries. The government makes money with it, thousands of people are employed within the industry, and yeah, millions of people are addicted to them. Weed didn't really become popular in the early industrialization of the modern world and thus not creating a market valuable to be exploited. I am no drug expert but when did weed become "popular" in the western civilization? The only thing I can remember is the Flower Power time in the 60s?
So yeah, I am not sure if introducing more drugs and creating the same dilemma we have with cigarettes and alcohol now because of the huge industry behind it, is in any way beneficial to mankind at all. Longtime goal should be to get rid of all of them, no?
-
Anu, no offense, but you have no idea what you're talking about. Marijuana is one of America's biggest cash crops. Marijuana has been illegal for like 1% of its lifespan. Before then, everyone around the world was using marijuana and hemp as medicine and thousands of other purposes including paper, VERY nutritional food, rope, pretty much anything you can think of. The reason it is still illegal is because of $$$$. pharmacies make shit tons of money developing and selling harmful chemical drugs with ridiculous side effects. Private prisons are cashing in when thousands of harmless pot smokers are thrown in jail. It sickens me how the government allows marijuana to be illegal so gangs can cash in, then police and law enforcement make big busts and act like they are heroes of America... It's a cycle of hypocrisy and greed.
Not to mention the cancer industry THRIVES off of marijuana being illegal. Do a little research on THC oil and cancer and you'll soon realize why corporations like The American Cancer Society want weed to stay illegal.
We're not introducing new drugs... Marijuana has been here and been used since the beginning of mankind. If you want a long term goal of eliminating the harmful drugs, legalization of marijuana is the best step to take. Who is going to go through the hassle of illegally obtaining cocaine or heroin or meth when they can buy marijuana at the local shop? I believe studies in Holland showed that after they eased up on marijuana, the usage of hard drugs and alcohol declined. The alcohol industry... another huge industry that lobbies against legalization of marijuana... it's really not that hard to figure out that greedy CEOs pretty much control everything in America
-
Well I quit smoking weed about 9 days ago and haven't had a single urge, saving up money for a few months then I might start again.
-
weed has killed many more ppl than alcohol
Husk, accompany bullshit with some humor so it's worth our time, please.
Yes to Shy, to put it simply, Marijuana itself prevents most of crimes associated with its trafficking.
If you were a strong weed user, I'm talking about daily usage for a year or more and you suddenly stopped using it you'd only feel lack of appetite for around 3 days (which can be easily solved by doing exercise those 3 days).
-
ropa, I may be wrong, but I think Husk is just spamming nonsense deliberately...
Edit: damn ropa that's weird I never knew that, I quit weed like 9 days ago, and all last week all I ate each day was like, 2/3 slices of toast, nothing more... I didn't eat tons more or anything, i've been on a diet for a while but for me I was really enjoying hardly eating, I actually hate eating these days I can't be bothered with it really...
I don't really eat these days until my stomach starts hurting, I really cba...Everytime I get hungry i'm like, FFS !
You got any more information on this?
-
shy, i agree with everything you said. all of it is true.
-
ropa, I may be wrong, but I think Husk is just spamming nonsense deliberately...
Edit: damn ropa that's weird I never knew that, I quit weed like 9 days ago, and all last week all I ate each day was like, 2/3 slices of toast, nothing more... I didn't eat tons more or anything, i've been on a diet for a while but for me I was really enjoying hardly eating, I actually hate eating these days I can't be bothered with it really...
I don't really eat these days until my stomach starts hurting, I really cba...Everytime I get hungry i'm like, FFS !
You got any more information on this?
Well, long use of weed can potentially mess up your stomach habits per say, but in most cases that's due to a lack of a healthy lifestyle.
I can only talk of assumptions and I doubt those will help you, visit a doc. Stomaches are the biggest weed addicts, yours might be suffering the abstinence syndrome.
-
what was topic again? who has done what drugs the most, wasnt it?
welcome to how threads used to be, stranger
here we talk about interesting shit
heil Selassie
(http://www.biografiasyvidas.com/biografia/h/fotos/haile_selassie.jpg)
-
Well, long use of weed can potentially mess up your stomach habits per say, but in most cases that's due to a lack of a healthy lifestyle.
I can only talk of assumptions and I doubt those will help you, visit a doc. Stomaches are the biggest weed addicts, yours might be suffering the abstinence syndrome.
Hmm, interesting, well, i've been ill for the past 2/3 weeks, but it's just a cold really so don't see why that would affect my hunger, it never has in the past...
My work is pretty demanding, i'm constantly moving for 9 hours a day, which is kinda why i'm losing weight along with not eating bacon/chips etc anymore, eatin sandwiches and fruit etc now...
I wouldn't say I have a healthy lifestyle, but think I can say it isn't an unfit lazy lifestyle anymore...
Was just wondering if quitting weed had anything to do with me not getting hungry as often as I was previously...
The less food the better for me, but don't want to risk damaging myself frm starvation or anything... Maybe I should start doing calorie diaries or something?
-
lol
move this to Off-topic or something
-
Due both to its common use as a recreational intoxicant and its employment in medicine, cannabis has been widely examined for its therapeutic potential and side effects. Among these side effects is tolerance, the regulation of cannabinoid uptake as a result of over stimulation. Tolerance is indicated by the requirement of larger doses to achieve a consistent desired effect, or when a given dose no longer provides it. Higher doses commonly result in the indication of higher impact of undesirable effects though, as with cannabinoids, tolerance can be achieved for many of these as well. Tolerance to cannabinoid stimulation results in withdrawal, most notably marked at 12 hours after cessation of “heavy” use by inner-unrest, increased activity and irritability. During a flushing period of 4 weeks following a 4 week daily ingestion period of 210 mg smoked THC, determined by Georgotas and Zeidenberg (comprehensive psychology), mild-withdrawal symptoms were reported to last between 5-7 days, with no inflammation or indication of desire for THC in the remaining 3 weeks.
Unlike the mythic ‘street-knowledge’ assay, which implies cannabinoid re-absorption through lipid deposits resulting in ‘occupied’ receptors due to constant stimulation, modern neuroassays have concluded tolerance to be based solely in receptor regulation. The cannabinoid content of endogenous lipid deposits has been shown to be less than active physiologically and psychologically.
A non-tolerant ingestion of smoked marijuana results in peak plasma concentrations of 90-95 ng/ml and peak effects lasting 75-90 minutes at which time plasma levels drop below psychoactive concentrations at 10 ng/ml. Plasma concentrations are unaltered by tolerance, indicating no change in endocannabinoid signaling, however cannabinoid stimulation, especially in ligand activation, decreases as a result of receptor based regulation. As has been widely explained and explored, availability of bonding-sites is reduced by down-tolerance and phosphorylation after prolonged or extreme exposure to cannabinoid agonists, resulting in a notable decrease in efficacy of stimulation and effects.
Various Cannabanoids are active at different receptors, both by their affinity for CB1 or CB2 or their digested distribution. As a result, specific tolerance occurs effecting specific site of action.
-Tolerance to the pharmacological effects of ataxia, analgesia, motor inhibition, and anticonvulsant activity usually occurs within 3-7 days of administration, depending on dose and frequency, as a result of cerebellum based CB1receptor-binding and WIN55,212-2 stimulation.
-Long-term memory inhibition, as well as certain neuroendocrine actions (including neuroprotective), take several weeks to develop tolerance desensitization, the former in part due to anandamide’s relatively high endogenous availability. Anandamide levels in the striatum show reduction after prolonged exposure to cannabinoid receptor agonists, though the availability of the precursors was not diminished, suggesting a superficial alteration of productivity.
-More resistant populations of CB1 receptors, primarily located in the limbic regions responsible for emotional stimulation, were uniquely resilient in prolonging the onset of tolerance regulation. Tolerance to immunosuppressive effects of CP-55,940 through stimulation of CB2 receptors is largely insignificant even over extended periods of exposure.
-CB1 activation in Hipocampal neuron populations responsible for short-term memory develops down-tolerance within 24 hours of Δ9-THC administration and showed no impact (positive or negative) from increased anadamide availability or administration.
-Cannabinoid analogues WIN55,212-2, CP-55,940 and 11-hydroxy-Δ8-THC, more infinitively specific cannabinoid agonists take 7-9 days to develop normal tolerance shown to take 3-7 days in administration of less-specific agonists. Due to their specific affinity for bonding efficiently with CB1 receptors (predominant site of CNS stimulant and psychoactive activity), tolerance develops more slowly than with less accurately coupled agonists such as Δ9-THC, CBN and CBD.
-In vitro cultures of neuroblastoma cell line (N18TG2) exhibited rapid-tolerance to chronic exposure to cannabinoid agonist stimulation, showing a natural cellular response.
Though tolerance and dependence often develop concomitantly, in the case of cannabinoid stimulation, since the primary actions of tolerance are neuroreceptive as opposed to adaptive endocannabinoid signaling, tolerance and dependence are independently significant. There is no scientific consensus on the implications of cannabinoid dependence and withdrawal. As there is no indication of somatic and/or neurovegetative periods after abrupt cessation of high-dose cannabinoid therapy, the criteria for physical dependence remain unfulfilled as defined by worldwide health ministries. Psychological withdrawal implications failed to appear in any animal study, though have occurred in human and some non-human primates, to a notably lesser degree than opiods. Primary indicated factors of “heavy” marijuana use behavioral withdrawal include irritability, sleep deficits, attentional deficits, and anxiety, and have been shown to noticeably recede within a 3-day period of cessation, dissipating completely within 1 week.
Recreational tolerance is relatively minute, if existent, in occasional users or ‘weekend-smokers’. Daily consumption for medicinal or recreational purposes however, can have greater, though still relatively diminutive, tolerance implications. Allowing receptor recuperation every 90 minutes could greatly decrease the impact of downregulation, and ingestion of appropriate doses rather than the commonly high recreational dose could aid in the resistance of phosphorylation tolerance. A recent study employing capsaicim antagonists and markers during Δ9-THC administration for analgesic property showed a low ceiling of consumption efficiency, followed by a rapid phosphorylation at high doses, implying a ‘sweet-spot’ theory, in which an exact dose is exponentially more efficient than an overdose. Recreational tolerance is relatively minute, if existent, in occasional users or ‘weekend-smokers’, due to the allowed recovery time. Daily consumption for medicinal or recreational purposes however, can have greater, though still relatively diminutive, tolerance implications. Forecasting scientific developments imply that through integration of specific agonists at specific bonding sites could reduce selective tolerance while achieving reasonable effects. The application of esoteric agonists could potentially alleviate tolerance based dosing and the complications it implies. Additionally, dosing with cannabinoid antagonists, such as CBD and CBG, can combat downregulation of receptors and expose increased availability.
The modification of protein residues is one of the most common mechanisms for protein regulation, at the synapse and elsewhere. Amongst the myriad of potential protein-modifications, the addition of functional groups (namely, phosphorylation and methylation) is highly-ubiquitous. The addition of functional groups may alter protein conformational states, thereby altering SARs and the magnitude of potential activation. This form of modification may also enhance or inhibit residue interactions necessary for ligand binding or dissociation- this may result in an increased or decreased affinity or efficacy. Additionally, protein modification may be used as a signaling residue for protein associations (i.e. receptor coupling, enhancement protein locking..etc.) or regulation (i.e. internalization, recycling or degradation). Nearly every protein studied reacts differently to different modifications, and most proteins utilize multiple simple-modifications.
Phosphorylation of CB1 receptors reduces CB1r-ligand binding efficacy in addition to targeting the protein for endosomal recycling. Phosphorylated CB1 receptors are quickly removed from the synapse (this process may begin within minutes of phosphorylation) and stored temporarily in a recycling endosome within the neuron (usually within the synaptic bouton), where it may be trafficked back to the surface or eventually degraded, depending on further signaling from the post-synaptic density.
The added consequence of this downregulation is a reduction in the size and quantity of synaptic protrusions. Just as the upregulation of synaptic proteins results in an increase in the size and overall quantity of synaptic protrusions by the addition of the endosomal liposome-components to the synapse in the process of vesicle fusion, receptor downregulation indicates the removal of synaptic material, resulting in a reduction in the density of synapse (see AMPAR-regulation at medium-spiny neurons in the NAc for a more thorough, well-studied example of this phenomenon). This overall reduction in synaptic connectivity has significant implications for the time-course of tolerance.
The explanation for this is a resistance to increased dosage/frequency. If the individual were to steadily increase his intake, he would most certainly still experience a tolerance. In the previous example, tolerance developed as a result of persistent administration and large doses. If that individual can remember the beginning of this 5 year period, he would likely note that he began with a sensitivity not unlike that which he experiences now. It is highly unlikely that he went from not smoking at all to wake-n-baking and dosing all day (this is called a 'loading-dose' followed by 'maintenance-doses' in pharmacology).
It is not difficult to ward off the development of tolerance with a resistance to the escalation of the frequency or quantity of dosing.
Though many individuals find that they are socially pressured into taking multiple hits off of a joint as it is passed around, most would do best to stay with their single-toke. A naive user, based on the quantity of cannabinoids on average in one modern marijuana cigarette, should take one deep breath and then step back. If the desired effect is not reached within 15-20min, another hit may be administered.
If this user is convinced that they would like a tolerance (I highly suggest that they stick with the method of sparse, small doses that they currently have and avoid doing so), the best method would be to increase the frequency of administration. If an increase in dose makes them uncomfortable, they might want to simply dose more often. This will cause an increase in tolerance, though not as rapidly. In all honesty though, there is nothing wrong with being sensitive to the effects of a drug-- know your body, know yourself- dose accordingly; that is the key.
CB-receptor distribution changes drastically from adolescence through adulthood. Many users find a significant difference between their response to the drug as a teenager and their response to a similar dose as an adult-- contrary to popular myth, this is not usually a product of 'super-potent modern killer-weed' or 'hyper-skunk' or whatever the media-outlets are labeling it these-days. This difference in response is a simple (or not so simple) matter of cannabinoid-receptor expression differences during development.
-
do you think there is somebody who will read all this? xD
-
next time please dont forget to copy the sources ;)
-
Yea good point Peja, Ramone's thesis on cannabis would've been blown off due to plagiarism for sure :P
Source: http://www.drugs-forum.com/forum/showthread.php?t=45944
-
do you think there is somebody who will read all this? xD
Komo :D
-
The biggest joke is, that cannabis is still on the doping list. Everybody who smoked weed knows that this cant be a push to better performance. It just shows that monkeys rule the world.
And good post Shy. Also good quote Ramone. xd
Without weed I would win more games, thats for sure. Thats not an exuse, its just the truth. But still, I guess I played over 10k games in my life. Just to be a little bit on topic.
I did say that some pages ago so dont think that weed f@#!s my brain.
-
we should form a hardcore stoners clan ;)
-
shy your parents knows you smoking cannabis everyday?
-
do you think there is somebody who will read all this? xD
Komo :D
I read about 1/3 of it and gave up cuz for the life of me I don't understand it...
Without weed I would win more games, thats for sure. Thats not an exuse, its just the truth. But still, I guess I played over 10k games in my life. Just to be a little bit on topic.
That's weird because when I smoke weed it actually helps me focus and concentrate and I ALWAYS get more done on weed than I do without, but then again I smoke Pollen not Grass or Soapy.
-
That's weird because when I smoke weed it actually helps me focus and concentrate and I ALWAYS get more done on weed than I do without, but then again I smoke Pollen not Grass or Soapy.
that's sativa for you. But what do you mean you smoke pollen? we all know that hash comes from cannabis but smoking hash is not smoking weed, you're using excessive amounts of tobacco for your health's sake.
I rarelly use sativa though (because I grow inside and the best seeds around here are indics) but I usually leave a pair of sativas every summer (autoflowering ones, only 2-3 months to cut leaving them outside with sunlight)
Shy, many great clans in the past formed from such initiative, PRO ROPERS ON DRUGS comes to mind, that clan was huge. Yeah, the tagname was PROD.
-
The only way I can explain pollen is like, it's inbetween soap bar and grass...
Grass being the strongest, soap bar is the cheapest crap full of nasty added stuff, pollen is in the middle, both price and strength and it's cleaner than soap bar but not as clean as grass.
If I smoke grass, I get extremely lazy and cba doing anything, if I smoke soapy it just makes me feel rough and kinda depressed, but pollen is perfect for me, it just makes me relax, focus and concentrate more, for example, I never get nervous playing League games for WA, I do when I don't smoke if it's elite or something...
Theres 2 types of stone i've heard, a head stone and a body stone, I prefer just headstone, I don't like my body to feel it so much.
I don't really know so much about weed, but people I know do and I just get it from them...
Also I like black, but it's not as common and hardly ever get it round here... I don't even know if these are Scottish terms or British terms or what, I just know it's what we all call all this stuff around here...
-
ah, ropa grows indoor. whats your setup? seeds you use?
-
ah, ropa grows indoor. whats your setup?
me and my roomate rented a dark room 1x1x2 we have another friend (in the same block) who has a clonebox (custom made)
besides that 2x 400w and 1x600w lights
a spudnik reflector + rvk extractor and that's it I think
seeds you use?
this is the last we put, i think plants had about a month of life, its the usual combo we usually put in, depends every time, but critical is the best type that grows here (and similars)
(http://i46.tinypic.com/fo194j.jpg)
-
I did that too with a friemNd some long time ago. The result was bad, we were absolute beginners. we made it from seeds and a single male one destroyed all the others. Well, we had billions of seeds created. :D
First post on my new ipad. cooool 8)
-
How a thread about "who has played WA the most" became a thread about drugs?
-
I had my interview today... Im guaranteed the job (grocery store cashier) as long as I pass the drug test, but she threw me a curveball... she said they would do a hair, urine, or blood test... Now I don't wanna believe that a small grocery store (Aldis) would do a hair test because it is expensive, but if they do, I'm going to fail it... I googled what other people applying for aldis had to do and they all said urine test, but just the fact that the interviewer said hair test makes me nervous. She's calling me back Monday to set everything up... what do you guys think?
-
Shave your head :D
-
I had my interview today... Im guaranteed the job (grocery store cashier) as long as I pass the drug test, but she threw me a curveball... she said they would do a hair, urine, or blood test... Now I don't wanna believe that a small grocery store (Aldis) would do a hair test because it is expensive, but if they do, I'm going to fail it... I googled what other people applying for aldis had to do and they all said urine test, but just the fact that the interviewer said hair test makes me nervous. She's calling me back Monday to set everything up... what do you guys think?
all assumption:
it wouldn't be rare if the company policy was "never be clear on what type of test it is so they can't get any feedback", because like you say, it sounds like too much of a cost but then again, I'm not familiar with the policies of the company/state/country and something like this would not surprise me at all. You can't do shit against a hair test, that's for sure.
-
@Nino, they would just take hair from somewhere else... I would have to get a full body wax haha.
@ropa, The way she told me about it sounded like she was just memorizing company policy. She was like "We have the authorization to perform a hair, blood, or urinary analysis for drug screening, blah blah blah." I think it's going to be urine for sure because like I said, i googled "aldis hair test" and I couldn't find a single post from someone who said they had to do a hair test, they all said they had to do a urine one
-
it's just a damn grocery store lol, I don't think you'll lose much if they won't hire you
-
true that lol.
-
:-\
-
it's just a damn grocery store lol, I don't think you'll lose much if they won't hire you
I'm a broke ass college student... The minimum wage in the US is $7.25 an hour and Ohio's minimum wage is $7.85... This grocery store starts out at $11.50 an hour, it's better than what I'm going to find in most other places looking for a summer job :P the possibility of a hair test is the only thing standing in my way
-
Yeah Shy, I was thinking same thing, you are a smart guy, I assume you have good qualifications, why the f@#! are you aiming for a shitty grocery store job in the 1st place? Even cashier, isn't aiming high... I only work in a supermarket (nightshift) because it's very hard for me to get another nightshift job with good money that's in the slightest bit intersting and isn't full of c@#!s... I enjoy working with working class, my people, for the banter...
Even if I hadn't said the above, why the hell does grocery stores bother doing drug tests? We don't do them over here, i've never had to do a drug test for a single job i've ever applied for and i've applied for quite alot in the past, with no mention of a drug test at all... Only job I would have had to take one was a train driver, but I didn't fancy the job so I didn't go for it...
Honestly, considering the low lifes (stereotypically speaking) shops normally hire, I can't believe you have to go through this for a shitty job at a supermarket... With you being the person you are, you are better than a supermarket man, you were on the f@#!ing radio for f@#! sake...!
*edit - just read your last post, I guess it makes sense*
-
well Komo, that's around 2.000 $ a month (if he does 40 hours a week) for what I'm sure is very little effort for him, so it sounds pretty good, university degree or not, specially since it's a summer job
-
I'm also trying to save up money so I can go to paramedic school next summer and eventually become a fireman (crossing my fingers for complete legalization soon, or I might move to Colorado for this... they do random drug tests). I plan on writing my screen plays as a fireman (they have a lot of free time, 24 hour shifts, next 48 - 72 hours off.) It's a good fallback job that doesn't require a full blown college degree. And yeah, the job is really easy - check people out and stock stuff when there's no one in line. I'd be working full time in the summer, so I'd make a good sum of money for doing monkey work, which I don't mind because it's contributing to my future goals
-
I'd make a good sum of money for doing monkey work, which I don't mind because it's contributing to my future goals
That's the part that makes sense :) Well, good luck man !
I apologise, I was under the impression you were settling for this job or something.
-
wudn't it be easier to, u know... just stop using drugs?
-
I'm also trying to save up money so I can go to paramedic school next summer and eventually become a fireman (crossing my fingers for complete legalization soon, or I might move to Colorado for this... they do random drug tests). I plan on writing my screen plays as a fireman (they have a lot of free time, 24 hour shifts, next 48 - 72 hours off.) It's a good fallback job that doesn't require a full blown college degree. And yeah, the job is really easy - check people out and stock stuff when there's no one in line. I'd be working full time in the summer, so I'd make a good sum of money for doing monkey work, which I don't mind because it's contributing to my future goals
you realize it is insanely hard to get a job as a fireman, right? even without you being a potsmoking fireman, that only makes it harder. it would be a shame to f@#! up a great job for marijuana. Weed isn't that great of a drug anyways, I always end up having less fun when I smoke weed. People just sit around and say stupid shit, you never seem to go out and do anything.
-
Weed isn't that great of a drug anyways, I always end up having less fun when I smoke weed. People just sit around and say stupid shit, you never seem to go out and do anything.
People are different, weed benefits me, it depends which type you smoke also, I don't care who believes what, but it's a good thing for me, although i've quit atm so I can save up money for a super PC.
Also, for me, weed is kinda like a favourite food, after a while it loses it's impact and I have to stop for a while so it becomes fresh again...
-
Weed isn't that great of a drug anyways, I always end up having less fun when I smoke weed. People just sit around and say stupid shit, you never seem to go out and do anything.
People are different, weed benefits me, it depends which type you smoke also, I don't care who believes what, but it's a good thing for me, although i've quit atm so I can save up money for a super PC.
Also, for me, weed is kinda like a favourite food, after a while it loses it's impact and I have to stop for a while so it becomes fresh again...
I'm biased though, I smoked up for years and years, then quit for a few years. When I tried smoking weed again, it made me paranoid every time I smoked and just wasn't fun anymore. Grew out of it. At the time it served its purpose, but i never wanted to be doing drugs or drinking heavily forever. To me there isn't anything more pathetic than a 40 or 50 year old alcoholic or burnout that leans on alcohol or drugs to cope with daily pressures.
-
heheheh walrus you are so right! i agree with everything you said! tho while im writing those lines im skoking a big joint, and i have to agreee that im enjoying it !!
-
yaaaaa man ! lets al"l get high and see who can plays the most w:a!
-
Hmm Wally, bl for you...
One of my mates was the same, but he only smoked it really because everyone else did, maybe u were the same? Was just something you grew up with? Some people aren't meant for it.
-
Hmm Wally, bl for you...
One of my mates was the same, but he only smoked it really because everyone else did, maybe u were the same? Was just something you grew up with? Some people aren't meant for it.
i started at age 13 and i smoked almost everyday from age 15 to 20. i loved pot at first smoking all those years, i remember warming with you way back when and we would take breaks to roll or take bong hits, ect. i even had a picture of me on cl2k mug shots blazing the weed. i would smoke now, but its just not the same. when i say i grew out of it i mean i changed my whole life to quit a host of other drugs and now not being in control or high bothers me. alcohol is fine, i even take a bunch of prescription pills, the more i talk about it the more i sound like a hypocrite, im not really drug free, i just have legal drugs now lol. im pretty sure people on here can relate because you have to be pretty addicted to computer games to get good at wa, thousands of games played in a year and such, ect. if i didnt feel like the police were coming to knock down the door wherever i am smoking weed, i would likely still be doing it.
-
I don't really know what I am talking about, but perhaps it's the other drugs that altered your mind Wally? I guess it's best to stop if that is how you feel...
Man, I am certain the longest warmers I ever played were with you, talking about hours and hours and hours lol, just getting f@#!ing stoned and roping for hours and hours and hours :D I wish I could say i'd love to do that again but whenever I try it's just not the same :( But I will cherish those moments for the rest of my life, such fun :)
-
i used to do coke to play WA
best days of my life
sadly, I don't make enough money
-
im pretty sure people on here can relate because you have to be pretty addicted to computer games to get good at wa, thousands of games played in a year and such, ect.
btw: here's the connection between "Who has played WA the most?" and all the drug stuff that is posted.
-
they question should be "who has played wa the most without drugs" ?
only a bunch of people left :D
-
i used to do coke to play WA
best days of my life
sadly, I don't make enough money
are you serious? does it helps for roping? xD
-
who played more or who uses or has used drugs over this discussion is ?
-
what? ???
-
i used to do coke to play WA
best days of my life
sadly, I don't make enough money
are you serious? does it helps for roping? xD
it helps you understand roping
-
it helps you understand roping
banned substance in any sport, you cheating chitchnap ;)
Learn to become one with the rope? That kind of understanding? :o
-
i personally dont smoke/drink but as I know quilz was a drug addicted freak, who knows where he is now, probably dead
-
it helps you understand roping
banned substance in any sport, you cheating chitchnap ;)
Learn to become one with the rope? That kind of understanding? :o
it gives you more concentration in whatever you're doing, so whilst you don't obtain hyper reflexes or superhuman timing, you might figure out how something works just because the high. You know, when it suddenly "ticks" and you're like, "wow, outlaws are this easy to do? hah!"
-
dats cheating, delete it to $Recycle.Bin
-
Okay, you're arguing that smoking weed is so much heathlier, but what about hygiene? You smell a lot by smoking weed everyday.. Maybe I'm more sensitive about this issue then others, but I wouldn't date a guy/girl who's smoking on a regular basis for sure ;P I'd prefer a guy that enjoys a beer and/or drink instead of smoke. What about girls? Don't girls rather prefer that you do alcohol instead of smoking in your country? That's how it is in Norway atleast.. I just dont understand your logic behind weed > alcohol. Easy choice for me ^^
-
I would rather have my girlfriend smoke pot than drink alcohol, but that's just me. If it is a choice between light smoking and light drinking, I would prefer smoking, but I wouldn't mind if the girl drank lightly. Alcohol is addictive and has a shit ton of health risks. I would completely fine if my girlfriend got high every night. I wouldn't be dating a girl that got drunk every night.
-
I would rather have my girlfriend smoke pot than drink alcohol, but that's just me. If it is a choice between light smoking and light drinking, I would prefer smoking, but I wouldn't mind if the girl drank lightly. Alcohol is addictive and has a shit ton of health risks. I would completely fine if my girlfriend got high every night. I wouldn't be dating a girl that got drunk every night.
you would rather have a girlfriend over both those options shy bahahaha :D
-
my girlfriend would have to be fine with me being a regular pot user ;)
-
my girlfriend never smoked a fag, never drank alcohol (she has tried wine and stuff but never got drunk per say), and she has no problem with me smoking pot with her. I obviously don't smoke in a closed room near her, always outside or in a very open place if I'm close.
Use Axe afterwards, and a toothbrush obligatory.
I would also rather have her smoke pot than get drunk every weekend. I mean, who wouldn't?
-
I am with ropa/shy on this one.
People are surprised I tell them I smoke weed, most people associate smoking weed with being a bum, and being lazy, and being thick, and I come across as neither of these... I am quite active and full of energy, I sleep as little as possible and I work hard when needed, If I can't be bothered doing something it's because I feel it isn't worth my effort, not cuz I can't be bothered to do it.
Anyone here the same?
-
@Ropa, that's a chance to leave in a warm country.. so you can smoke outside ;)
@Komo: When I smoke I become a big lazy bitch :) Well actually it depends the kind and the quantity of weed, but most of the time, i'm just getting lazy ;) And that's acutally the reason why i'm only smoking occasionally now
-
Yah that's why I avoid grass DoGG lol, it DOES make me lazy, it's Pollen I smoke, diff type of weed :D
-
@Ropa, that's a chance to leave in a warm country.. so you can smoke outside ;)
@Komo: When I smoke I become a big lazy bitch :) Well actually it depends the kind and the quantity of weed, but most of the time, i'm just getting lazy ;) And that's acutally the reason why i'm only smoking occasionally now
I also get physically lazy when I smoke but that doesn't stop me from doing paper work or reading, many little things beat smoking good weed and reading a good novel. It's all about the right dose at the right time, and there's nothing stopping you from being a wall street shark or a mountain hiking guide.
-
Yeah right guys, I don't know the difference between grass/pollen/whatever but i know some weeds are more "high" and some others are more "stone". And it's true with the correct weed and the correct dose, you can have nice creativity + motivation raising up! It's a rare case tho, and couldnt tell exactly how to reproduce it! I guess it's also very related to the current mood, which can be subconscious
-
Personally speaking, i've probably tried close to 100 different types of smoke, Soap/Black/Grass/Pollen, over about, 16 years (yes, I started when I was 11, my big brother was 14).
I've smoked stuff that made me incredibly sick, incredibly lazy, incredibly paranoid, I eventually found what works for me.
-
8)
-
I have my own style since years. There are guys smoking weed without tabacco, there are some with half-half. My ones are maybe 1:20 so its a lot of tabacco inside. I just need about 4 gr.a week. Im addicted to nicotine and this really f@#!ing me off. I tried many times to stop it but couldnt for some reasons.
And ofc I would always prefer a pot smoking babe than alcoholic one. What a question..but maybe thats why you different, Crazy 8)
I do 1gr a day, 1 cig lasts me 3 joints, but I use the orange part (with hard paper inside) so I end up wasting lots of tabacco... we could trade x)
for me, weed has totally solved my tobacco addiction, and I only use tobacco to protect my throat, as funny as that might sound, an all green of interior weed is really hard no matter how hardcore of a smoker you are.
-
thank you, SPW!
-
Getting super high and watching Twin Peaks is like one of my favorite things to do haha
-
hmmmm could this topic be cleansed from all this drug abuse talk? maybe just delete them or move to different topic?
I don't see any talk of abuse.
maybe someone in your family did abuse it and died and that's why you're such a sensitive flanders?
-
Getting super high and watching Twin Peaks is like one of my favorite things to do haha
lol twin peaks. i actually drove through the town that show was inspired by this summer when i visited my sister in washington.
-
that's awesome! It's definitely in my top 3 favorite tv shows ever
-
topic free ;)
-
I do 1gr a day
everyday?? that's a lot.. :o
-
I do 1gr a day
everyday?? that's a lot.. :o
It's like 3 cups of wine a day :)
-
hmmmm could this topic be cleansed from all this drug abuse talk? maybe just delete them or move to different topic?
I don't see any talk of abuse.
I do 1gr a day
everyday?? that's a lot.. :o
It's like 3 cups of wine a day :)
maybe someone in your family did abuse it and died and that's why you're such a sensitive flanders?
yes, ur mom
-
Do you guys lose weight after taking a break from weed? 'Tis been 3 weeks without smoking due to focusing 100% on rl stuff and I've lost like 5kg.
-
Do you guys lose weight after taking a break from weed? 'Tis been 3 weeks without smoking due to focusing 100% on rl stuff and I've lost like 5kg.
tienes que mover mas el culo para hacer hambre :P
-
Do you guys lose weight after taking a break from weed? 'Tis been 3 weeks without smoking due to focusing 100% on rl stuff and I've lost like 5kg.
it might just be that you eat more when you're high... it's called having the munchies, idk if that's a universal term, but I always eat a lot when I'm high
-
Do you guys lose weight after taking a break from weed? 'Tis been 3 weeks without smoking due to focusing 100% on rl stuff and I've lost like 5kg.
lol probably because when you are stoned you are always hungry!!
-
This is just when you smoke from time to time. When smoking daily, you dont get those food attacks, imo.
Thanks for the work mod to split topics. :)
-
This is just when you smoke from time to time. When smoking daily, you dont get those food attacks, imo.
Thanks for the work mod to split topics. :)
I am the same, I don't really get extra hungry at all when smoking, it makes me enjoy chocolate more, but I very very very rarely eat chocolate these days, I am way more a savoury guy :D
-
SPW you're a hero
-
SPW you're a hero
Huh? :o
-
https://www.tus-wa.com/files/file-402/ (https://www.tus-wa.com/files/file-402/)
-
http://www.usingenglish.com/reference/irregular-verbs/split.html
-
so we can talk about steroids here too?
;D
-
This is just when you smoke from time to time. When smoking daily, you dont get those food attacks, imo.
Thanks for the work mod to split topics. :)
yeah i dont get the munchies either, but i know some people that smoke everyday and eat a shitload
-
Guess they would eat anyway, with or without weed. A different drug. xd
-
.