I am a movie junkie, with favorites going back to the 60's, but my favorite overall:
Amélie
It has a fantastic score, the cinematography and use of color is perfect, the story is cute and awkward and uplifting, the main character (Tautou) is a babe, it has a wonderful, happy ending that will make you feel good, etc.
I can think of tons of great films, but this one takes the cake.
I also love films by directors such as David Lynch, Roman Pulanski, Gregg Araki, Woody Allen, Gaspar Noe, Richard Linklater, Wes Anderson, Stanley Kubrick, Alejandro González Iñárritu, Tim Burton, John Hughes, Luc Besson, Andrei Tarkovsky, James Cameron, etc.